Stanolean 10

Stanolean 10 is an oral androgen, a derivative of Dihydrotestosterone (DHT). Stanozolol was originally developed to treat hereditary angioedema. As with most Androgens Stanozolol will help to create a state of anabolism and contribute to a significant increase in muscle tissue. Structurally, stanozolol is not capable of converting into estrogen therefore will not contribute to water retention which may be the case with other androgens. Also unlike most anabolic steroids, is not esterified. The drug has a large oral bioavailability, due to a C17 a-alkylation which allows the hormone to survive first pass liver metabolism when ingested.

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COMPOSITION:

Each tablet ccntains: Stanozolol 10 mg
Excipients.........q.s.

DESCRIPTION:

Stanolean 10 is an oral androgen, a derivative of Dihydrotestosterone (DHT). Stanozolol was originally developed to treat hereditary angioedema. As with most Androgens Stanozolol will help to create a state of anabolism and contribute to a significant increase in muscle tissue. Structurally, stanozolol is not capable of converting into estrogen therefore will not contribute to water retention which may be the case with other androgens. Also unlike most anabolic steroids, is not esterified. The drug has a large oral bioavailability, due to a C17 a-alkylation which allows the hormone to survive first pass liver metabolism when ingested.

CLINICAL PHARMACOLOGY:

Endogenous androgens such as testosterone are responsible for the development and growth of the male sexual organs and post-adolescent secondary sex characteristics. Androgen effects include but are not limited to the maturation of the penis, scrotum, prostate, seminal tubules, laryngeal enlargement, vocal ccrd thickening, changes in muscle mass and fat distribution, and the development and distribution of male hair (facial, pubic, chest, back, axillary). Androgens are responsible for the growth spurt of adolescence and the aromatization of androgens to estrogens for the eventual termination of linear growth, which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietin stimulating factor. Androgens may suppress gonadotrophic function of the pituitary. During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). With large doses, spenmatogenesis may be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

DRUG INTERACTIONS:

Stanozolol may increase sensitivity to anticoagulants; therefore, dosage of anticoagulants may have to be decreased in order to maintain the prothrombin lime at the desired therapeutic level. Anti-diabetic drugs and Insulin: In diabetic patients, the metabolic effects of androgens may reduce blood glucose, insulin, and anti-diabetic medication requirements. Adrenal steroids or ACTH: May exacerbate edema in patients on concurrent adrenal-cortical steroids or ACTH therapy. Anticoagulants: Patients on anticoagulants such as warfarin should be carefully monitored during androgen therapy as androgens may increase sensitivity to oral anticoagulants which may require a concomitant reduction in anticoagulant dosage to achieve a desirable prothrombin time (PT). Concurrent use of anti-diabetic agents, insulin, cyclosporines, hepatotoxic medications, and/or human growth hormone (somatropin) has been reported to decrease anticoagulant requirements. Anticoagulant patients should be monitored regularly during androgen therapy, particularty during initiation and termination of therapy.

CONTRAINDICATIONS :

Not intended for use in children. Known or suspected prostatic carcinoma and mammary carcinoma in the male. Not intended foruse in female patients other than those with disseminated breast cancer. Contraindicated in nephrosis or the nephrotic phase of nephritis, cardiac and renal failure,hypercalcaemia, oedema, jaundice, liver disease with impaired bilirubin excretion, testicular and hepatic carcinoma.

WARNINGS:

This product can be used only by healthy adults over 18 years old. Carefully read directions before using this product. Consult your physician before using this product if you are taking any prescription or over the counter drugs or supplements. KEEP AWAY FROM CHILDREN.

SIDE EFFECTS:

Males: Frequent or persistent penile erections and increases in the appearance of acne vulgaris. Females: Hoarseness of the voice, acne, changes in menstrual periods, or more facial hair.

DOSAGE AND ADMINISTRATION:

Adult male: Daily dosage of 10 mg to 40 mg in 2 to 4 divided doses may be required to achieve the desired response.

STORAGE:

Do not refrigerate or freeze. Do not store above 30 C. Protect from direct sunlight.

PACKAGE :

60 Tablets USP