Xandrol 10

COMPOSITION:

Each tablet ccntains: Oxandrolone 10 mg
Excipients.......q.s.

DESCRIPTION:

Oxandrolone is a mild, low androgen 17-alpha alkylated anabolic steroid with very low toxicity. It promotes protein anabolism and has a low incidence of adverse reactions. Oxandrolone is primarily used to promote strength, muscle hardness and quality physique improvement. In the International Journal of Obesity, (1995; 19: 614-624), it was shown that Oxandrolone enhanced body fat reduction significantly in both the abdominal and visceral stores. Oxandrolone will not aromatize, and therefore the anabolic effect of this compound can actually promote linear growth.

CLINICAL PHARMACOLOGY:

Endogenous androgens such as testosterone are responsible for the development and growth of the male sexual organs and post-adolescent secondary sex characteristics. Androgen effects include but are not limited to the maturation of the penis, scrotum, prostate, seminal tubules, laryngeal enlargement, vocal ccrd thickening, changes in muscle mass and fat distribution, and the development and distribution of male hair (facial, pubic, chest, back, axillary). Androgens are responsible for the growth spurt of adolescence and the aromatization of androgens to estrogens for the eventual termination of linear growth, which is brought about by fusion of the epiphyseal growth centers. In children, exogenous androgens accelerate linear growth rates but may cause a disproportionate advancement in bone maturation. Use over long periods may result in fusion of the epiphyseal growth centers and termination of the growth process. Androgens have been reported to stimulate the production of red blood cells by enhancing the production of erythropoietin stimulating factor. Androgens may suppress gonadotrophic function of the pituitary. During exogenous administration of androgens, endogenous testosterone release is inhibited through feedback inhibition of pituitary luteinizing hormone (LH). With large doses, spermatogenesis may be suppressed through feedback inhibition of pituitary follicle stimulating hormone (FSH).

DRUG INTERACTIONS:

Oral hypoglycemic agents: Oxandrolone may inhibit the metabolism of oral hypoglycemic agents which may require adjustment of dosage. Adrenal steroids or ACTH: Oxandrolone may exacerbate edema in patients on concurrent adrenal-cortical steroids or ACTH therapy. Anticoagulants: Patients on anticoagulants such as warfarin should be carefully monitored during anabolic steroid therapy as anabolic steroids may increase sensitivity to oral anticoagulants which may require a concomitant reduction in anticoagulant dosage to achieve a desirable prothrombin time (PT). Anticoagulant patients should be monitored regularly during anabolic steroid therapy, particularly during initiation and termination of therapy. Warfarin patients should have INR and PT monitored throughout androgen therapy and warfarin dosages titrated to achieve the desired INR and PT. Such patients should be monitored for occult bleeding.

CONTRAINDICATIONS:

Not intended for use in children. Known or suspected prostatic carcinoma and mammary carcinoma in the male. Not intended foruse in female patients other than those with disseminated breast cancer. Contraindicated in nephrosis or the nephrotic phase of nephritis, cardiac and renal failure,hypercalcaemia, oedema, jaundice, liver disease with impaired bilirubin excretion, testicular and hepatic carcinoma.

WARNINGS:

This product can be used only by healthy adults over 18 years old. Carefully read directions before using this product. Consult your physician before using this product if you are taking any prescription or over the ccunter drugs or supplements. KEEP AWAY FROM CHILDREN.

SIDE EFFECTS:

Males: Frequent or persistent penile erections and increases in the appearance of acne vulgaris. Females: Hoarseness of the voice, acne, changes in menstrual periods, or more facial hair. DOSAGE AND ADMINISTRATION:

Adult male: Daily dosage of 5 mg to 20 mg in 2 to 4 divided doses may be required to achieve the desired response.

STORAGE:

Do not refrigerate or freeze. Do not store above 30 C. Protect from direct sunlight.

PACKAGE :

60 Tablets USP